Abstract
RNA molecules undergo dynamic chemical modifications in response to various external or cellular stimuli. Some of those modifications have been demonstrated to post-transcriptionally modulate the RNA transcription, localization, stability, translation, and degradation, ultimately tuning the fate decisions and function of mammalian cells, particularly Tcells. As a crucial part of adaptive immunity, Tcells play fundamental roles in defending against infections and tumor cells. Recent findings have illuminated the importance of RNA modifications in modulating Tcell survival, proliferation, differentiation, and functional activities. Therefore, understanding the epi-transcriptomic control of Tcell biology enables a potential avenue for manipulating Tcell immunity. This review aims to elucidate the physiological and pathological roles of internal RNA modifications in Tcell development, differentiation, and functionality drawn from current literature, with the goal of inspiring new insights for future investigations and providing novel prospects for Tcell-based immunotherapy.
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