The physiological and biochemical methods of increasing of energy diffusion in vivo as a reaction of compensation under obesity.

Abstract

The article presents the analysis concerning main directions of physiological increasing of expenditure of energy in organism that probably can be used for prevention of obesity. First of all, it's increasing of physical load and activation of heat production at cold adaptation. In both cases the leading role belongs to skeletal muscles and consists in both implementation of biological function of locomotion and regulation of metabolism. At human biological reaction of adaptation to lower temperatures the most significant increasing of energy scattering in the form of heat is provided by cross-striated muscle fibers at the expense of contracticle function (thermo-regulation muscle tone and tremble) and increasing of uncoupling of oxidation and phosphorylation in mitochondria and also increasing of activity of cellular pumps: Na+, К+- ATPase and Ca-ATPase for compensation of increased passive "leakage" of ions. This occurrence is induced by action of nor-adrenaline and thyroid hormones and is accompanied by activation of hydrolysis of triglycerides and oxidation of released fatty acids in mitochondria. To develop biological reaction of cold adaptation and also prevention of obesity a proposal is made to implement both common procedures of tempering and short-time impact of ultra-low temperature in the conditions of specialized cryo-sauna.