The Physiologic Basis for Therapy of Classic Hemophilia (Factor VIII Deficiency) and Related Disorders

Abstract

Clinical Staff Conference1 October 1967The Physiologic Basis for Therapy of Classic Hemophilia (Factor VIII Deficiency) and Related DisordersCombined Clinical Staff Conference at the National Institutes of HealthN. RAPHAEL SHULMAN, M.D., DALE H. COWAN, M.D., EUGENE P. LIBRE, M.D., STANLEY P. WATKINS JR., M.D., VICTOR J. MARDER, M.D.N. RAPHAEL SHULMAN, M.D.Search for more papers by this author, DALE H. COWAN, M.D.Search for more papers by this author, EUGENE P. LIBRE, M.D.Search for more papers by this author, STANLEY P. WATKINS JR., M.D.Search for more papers by this author, VICTOR J. MARDER, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-67-4-856 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptDr. N. Raphael Shulman: In the past few years much new information has been acquired concerning the pathophysiology and therapy of classic hemophilia and other diseases involving factor VIII deficiency. Most important has been a revolution in treatment permitted by the availability of factor VIII concentrates. Hemostasis in hemophiliacs, which several years ago presented a difficult if not hopeless problem, now can be managed with complete effectiveness in a rather routine manner. In addition, there is a clearer concept of the genetic control of factor VIII, provided chiefly by studies of von Willebrand's disease; and recently, there have been some...