Abstract
The majority of DNA in living cells is strongly bent. However, this strong bending regime is poorly understood. While the weak bending regime can be approximated by Hooke's law, it is not clear if that is still valid for large bending angles. The experimental evidence is controversial. We explore the strong bending regime of the double helix using a model that represents the solvent implicitly, which allows for greater efficiency. First, we are able to reproduce results of Strauss and Maher. Next, we compare the energetics of weakly and strongly bent DNA. We find that Hooke's law is violated for strongly bent DNA and discuss the energetic contribution that may be responsible for the effect.
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