Abstract

Abbreviations I. Overview 2. General introduction 2.1. Myelin 2.2. Myelination 2.3. Myelin basic protein 2.4. Protein phosphorylation 3. Protein kinases that act on myelin basic protein 3.1. Cyclic AMP-dependent kinase 3.2. Calcium-dependent kinases 3.3. Other kinases 4. Phosphoprotein phosphatases that act on myelin basic protein 5. Phosphorylation of myelin basic protein/n vitro 5.1. In vitro methods in the study of myelin basic protein phosphorylation 5.1.1. Myelin preparations 5.1.2. Incubation of optic nerve 5.1.3. Cell cultures 5.2. Covalent attachment of polyphosphoinositides to myelin basic protein 5.3. Phosphoramide bonds in myelin basic protein 6. Phosphorylation of myelin basic protein/n vivo 7. Phosphorylation of other myelin proteins 7.1. Myelin basic protein-related polypeptides 7.2. 2',Y-Cyciic nucieotide Y-phosphohydrolase 7.3. P0 7.4. Myelin-associated glycoprotein 8. General discussion 8.1. Myelin basic protein phosphorylation in the oligodendrocyte 8.2. Myelin basic protein phosphorylation in the myelin sheath 8.3. Regulation of myelin basic protein phosphorylation Acknowledgements References 241 241 242 242 242 242 245 245 245 245 248 248 248 248 248 249 249 249 250 250 251 251 251 252 252 252 252 254 254 255 255

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