Abstract
The greatest challenges of modern pharmacology are the design of drugs with the highest possible efficacy of an active substance and with the lowest possible invasiveness for the whole organism. A good solution features the application of a bioactive substance in different carriers. The effectiveness of such preparations is determined not only by the properties of the drug, but primarily by the dynamics of carrier movement in the body. This is the reason why studies on the dispersed systems transport in micro- and nanostructures are becoming important. This paper presents a study of emulsion systems transport in microcapillaries. A dispersed phase thickening effect was observed during the process, which resulted in a concentration increase of the flowing emulsion, in some cases up to 10 times. This phenomenon directly influences transport dynamics of such substances in microstructures and should be taken into account when designing drug parameters (concentration, release time, and action range). The effect was investigated for three different emulsions concentrations and presented quantitatively. The scales of this phenomenon occurrence at different flow conditions were investigated, and their magnitudes were modelled and described. This allows the prediction of the flow resistance in the movement of given dispersion systems, as a function of the flow rate, the emulsion parameters, and the microchannel size.
Highlights
The main goal of modern pharmacology is to design such drugs that will allow the delivery of an appropriate dose of therapeutic substances to a specific site in the body without exposing the whole organism to excessive contact with them
Based on microscopic image analysis, it was possible to determine what fraction was occupied by oil droplets in relation to the total
Based on the work carried out, it was found that under certain flow conditions, there was a phenomenon of accumulation of oil droplets in a channel structure
Summary
The main goal of modern pharmacology is to design such drugs that will allow the delivery of an appropriate dose of therapeutic substances to a specific site in the body without exposing the whole organism to excessive contact with them The transport of these substances occurs in ducts formed in biological systems. It can be main arteries and veins as well as microcapillaries with blood transport. For this reason, in recent years, there has been an increasing use of various types of active substances carriers, of which emulsion carriers are one of the simplest forms [1].
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