Abstract
Inside the nucleus of an intact cell, DNA is folded around histone proteins into nucleosomes and compacted into a multi-layered three-dimensional chromatin network. The nanometre spacing between nucleosomes positioned throughout this structural framework is known to locally modulate local DNA template access and regulate genome function. However, given that this structural feature occurs on a spatial scale well below the diffraction limit, real time observation of nucleosome proximity in live cells by optical microscopy has proven technically difficult, despite recent advances in live cell super resolution imaging.
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