Abstract
BackgroundA nationwide investigation on the carriage proportion of H. influenzae among healthy populations is lacking in China. The purpose of the study was to review the prevalence of pharyngeal carriage of H. influenzae among healthy populations in China, and explore its influencing factors. The serotypes distribution of H. influenzae was also analyzed.MethodsA systematic search was conducted with key words “Haemophilus influenzae”, “Carriage”, and “China” or “Chinese” from inception to March 2018. After careful screening, the data of included articles were extracted with a pre-designed excel form. Then, the pooled carriage proportion of H. influenzae was calculated using the random effect model.ResultsA total of 42 studies with 17,388 participants were included. The overall pooled carriage proportion of H. influenzae was 0.17 (95% CI: 0.13–0.21), and the carriage proportion largely varied by province. Subgroup analysis indicated that the pooled carriage proportion was 0.17 (0.13–0.21) for children, and 0.14 (0.7–0.23) for adults. There were no statistically significant heterogeneity between subgroups by age (p = 0.65), sex (p = 0.88), and season (p = 0.10). The pooled carriage proportion of Hib was 0.01 (0–0.02), while the carriage proportion of NTHi was 0.22 (0.13–0.31).ConclusionIn China, the carriage proportion of H. influenzae among healthy population was low, but it largely varied by provinces.
Highlights
A nationwide investigation on the carriage proportion of H. influenzae among healthy populations is lacking in China
The pooled carriage proportion of H. influenzae by provinces were calculated, and a statistical map was generated using an online website for mapmaking
Our results indicated that the carriage proportion of Non-typeable Haemophilus Influenza (NTHi) was 0.22 among Chinese healthy population, which makes it a public health issue worthy of attention
Summary
A nationwide investigation on the carriage proportion of H. influenzae among healthy populations is lacking in China. The purpose of the study was to review the prevalence of pharyngeal carriage of H. influenzae among healthy populations in China, and explore its influencing factors. In China, up to now, many studies investigated the pharyngeal carriage of H. influenzae among healthy populations. [5] tested the nasopharyngeal swabs of 472 children aged 2–5 years old in Beijing and found that the carriage proportion of H. influenzae was 0.095. All of these studies were conducted in specific regions and the results of these studies substantially varied, given the vast territory and population of China. The nationwide investigation on the carriage of H. influenzae among healthy people is lacking
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