Abstract
Abstract (±)-1-(4′-Hydroxybenzyl(-2-methyl-6-methoxy-7-ethoxy-1:2:3:4-tetrahydro-isoquinoline and its dextrorotatory and laevorotatory isomers and methochloride, (±)-1 -(4′-hydroxybenzyl)-2-methyl-7-methoxy-6-ethoxy-1:2:3:4-tetrahydro-isoquinoline, its laevorotatory isomer and methochloride and a berberine-like compound related to tetrahydroworenine have been tested for curare-like activity. Little activity was noted, but on the rat diaphragm and frog rectus muscle quaternisation of the racemic compounds increased this. The tertiary bases possessed potent convulsant properties.
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