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Abstract
Interhemispheric connections across the corpus callosum may have inhibitory or excitatory effects on signal propagation. Previous transcranial magnetic stimulation (TMS) research suggests that transcallosal fibers inhibit the propagation of activity between homologous brain regions; however, transcallosal disinhibition occurs in the presence of a TMS paradigm related to GABAB receptor-mediated inhibitory neurotransmission. We investigated the neurochemical mechanisms involved in interhemispheric connectivity by conducting a randomized, double-blind, controlled within-subjects study measuring TMS-induced interhemispheric signal propagation (ISP) with electroencephalography (EEG) recordings under the effects of baclofen, L-DOPA, dextromethorphan, and rivastigmine. We hypothesized that the administration of GABAB receptor agonist baclofen would decrease ISP when compared against placebo, thus leading to greater interhemispheric inhibition.
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