Abstract
Responses of the dog urinary bladder and its vascular bed to various coin-pounds administered into the caudal vesical arteries were investigated under blood perfusion at a constant rate. TEA, physostigmine, phenylephrine, 5-hydroxytryptamine, angiotensin II, lys-vasopressin, oxytocin and ergotamine caused a contraction of the bladder and constriction of the vesical vascular bed. Acetylcholine, bethanechol, carbachol, TMA, lobeline, nicotine, DMPP, neostigmine, histamine, bradykinin, eledoisin, kallikrein, ATP, KCl and morphine produced a contraction of the bladder and dilation of the vesical vascular bed. Noradrenaline, adrenaline, dopamine and tyramine caused a relaxation of the bladder and vasoconstriction. Only isoprenaline produced a, relaxation of the bladder and vasodilation. Ephedrine and methoxamine constricted the vesical vascular bed but exerted no effect on the bladder itself. Aminophylline, dipyridamole, hydralazine, nitroglycerin, papaverine, adenosine, AMP, ADP, UMP, UDP, UTP, DPN, TPN, procaine and tetrodotoxin dilated the vesical vascular bed with-out affecting the bladder. These results indicate that the vesical vascular bed has pharmacological characteristics of its own.
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