Abstract
Several species of Magnoliaceae and Annonaceae are used in Traditional Chinese Medicine. (−)-Anonaine, isolated from several species of Magnoliaceae and Annonaceae, presents antiplasmodial, antibacterial, antifungal, antioxidation, anticancer, antidepression, and vasorelaxant activity. This article provides an overview of the pharmacological functions of (−)-anonaine.
Highlights
Various constituents of Michelia alba (Magnoliaceae) are used for medical purposes
In human cervical cancer cell (HeLa), (−)-anonaine caused DNA damage associated with increased intracellular nitric oxide, reactive oxygen species (ROS), glutathione (GSH) depletion, disruptive mitochondrial transmembrane potential, activation caspase 3, 7, 8 & 9 activation and poly ADP ribose polymerase cleavage [15]
One study has shown that 1,2-dimethoxy-5,6,6a,7-tetrahydro-4H-dibenzoquinoline3,8,9,10-tetraol, (−)-anonaine, liriodenine, and nornuciferine are the main constituents of the aerial parts of Annona cherimola [2]
Summary
We have identified a series of compounds from Michelia alba, including (−)-anonaine (Figure 1A) [1], an aporphine (isoquinoline) alkaloid isolated from other plants (Table 1) with interesting and varied biological and pharmacological activities, including vasorelaxant, antibacterial, antifungal, antioxidative, anticancer and antidepressant effects, as summarized in Table 1 [1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20,21,22,23,24,25,26,27,28,29,30,31,32]. We will focus on describing the pharmacological mechanisms of action of (−)-anonaine
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