Abstract
The duration of pharmacologic effects and the plasma half-life of glyceryl guaiacolate ether (GGE) were shorter in adult male than in adult female rats. The sex-dependent variation resulted from a high activity of O-demethylase in male rats and a low activity in female rats. The kinetic data obtained on O-demethylase from liver microsomes of both male and female rats indicated that the Michaelis constants for the two sexes were similar. This, coupled with a greater maximal velocity value observed for the oxidation of GGE by O-demethylase of male rats, suggested a quantitative rather than a qualitative difference between the O-demethylase of male and female rats.
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