Abstract
The pharmacokinetics of mianserin were examined in eight elderly depressed patients following a single oral dose of 60 mg. Plasma concentrations were measured by gas chromatography / mass spectrometry and the data analyzed using a two-compartment open model. Mean (± SD) estimates were: absorption half-life 0.8 ± 1.0h, peak concentration 117 ± 23 μg/1, peak time 2.2 ± 1.3h, distribution half-life 3.4 ± 1.2h, elimination half-life 33 ± 15h, apparent volume of distribution 20.2 ± 7.91/kg, and oral clearance 0.49 ± 0.211/kg/h. These parameters were not significantly different from those found in healthy volunteers. The absorption lag time (0.6 ± 0.2h) and area under the curve (2009 ± 566μg/1/h) were significantly different in the elderly. The clinical implications of these differences for the treatment of elderly depressed patients are discussed.
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