Year-end Sale % OFF 
Abstract
Abstract The metabolism of cyclophosphamide was determined before and following treatment with methotrexate. After 9 days treatment to 7 patients with methotrexate 7.5 mg/day by mouth the rate of bio‐transformation of cyclophosphamide was decreased in 2 cases, increased in 1 case and unchanged in 5 cases. After the intravenous injection of 40 mg methotrexate to 2 subjects the biotransformation of cyclophosphamide is immediately inhibited. It is argued that the inconsistency of the results after prolonged treatment with methotrexate may be due to individual variations with regard to sensitivity of the drug metabolizing enzymes to methotrexate, whereas the acute effect is probably due to an inhibition of the action of the enzymes.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
