Abstract
BackgroundConsidering the importance of having a celiac disease-specific measure of the quality of life (QOL) in Persian, the present study aimed to translate the celiac disease quality of life questionnaire (CDQOL) into Persian and evaluate its psychometric properties.MethodsIn this cross-sectional study, the Forward–Backward translation method was used. The content validation ratio (CVR) and the content validity index (CVI) were used for content validity assessment. The construct validity was assessed by exploratory factor analysis (EFA) and confirmatory factor analysis (CFA) on 220 celiac patients who were selected randomly from the celiac disease (CD) registry database. The correlations between the result of the Persian version of CDQOL (PCDQOL), self-rated QOL, and short form-36 (SF36) were analyzed using the Pearson correlation test. The internal consistency and test–retest reliability were measured through Cronbach’s alpha and intraclass correlation coefficient (ICC).ResultsIn the present study, 220 celiac patients with a mean age of 35.54 ± 10.29 years participated. The mean CVI, CVR, and impact score of PCDQOL were 0.98, 0.96, and 4.82 respectively. Using EFA, four factors have extracted that had a good fit in CFA (Chi-square/DF = 1.74, RMSEA: 0.08, and CFI: 0.90, and NFI: 0.90). The results showed that there was a moderate to high correlation between PCDQOL, SF36 (r: 0.587, p = 0.02), and self-rated QOL (r: 0.64, p < 0.001). The questionnaire had high internal consistency (Cronbach alpha: 0.93) and test–retest reliability (ICC: 0.96 [0.86–0.99]).ConclusionThe PCDQOL questionnaire could be used by physicians and nutritionists to assess HRQOL in celiac patients in Iran.
Highlights
Considering the importance of having a celiac disease-specific measure of the quality of life (QOL) in Persian, the present study aimed to translate the celiac disease quality of life questionnaire (CDQOL) into Persian and evaluate its psychometric properties
The Celiac disease (CD) could negatively affect the quality of life (QOL) of patients and some studies showed that adherence to gluten-free diet (GFD) could improve the QOL in this population
In the present explorative cross-sectional study, the English version of the CDQOL questionnaire was translated to Persian and its face, content, and construct validities as well as its reliability, was examined
Summary
Considering the importance of having a celiac disease-specific measure of the quality of life (QOL) in Persian, the present study aimed to translate the celiac disease quality of life questionnaire (CDQOL) into Persian and evaluate its psychometric properties. Celiac disease (CD) is an immune reaction to eating gluten in people with genetic susceptibility. According to the result of a recent systematic review, CD is a common disease with a prevalence of 0.7 to 1% [1]. A strict, life-long gluten-free diet (GFD) is the only available treatment for CD [3]. In this diet, all gluten-containing foods should be eliminated from the diet. Considering that gluten is found in a wide range of foods, adherence to GFD is challenging [4]. The CD could negatively affect the quality of life (QOL) of patients and some studies showed that adherence to GFD could improve the QOL in this population
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