Abstract
The permeability of the blood-brain barrier and of the cell membranes to intravenously (i.v.) injected horseradish peroxidase was investigated in rats after 4 days with urease-induced hyperammonaemia. Increased permeability across the vessels was not observed. The endothelial tight junctions were intact, and the clefts between adjacent endothelial cells were devoid of reaction product. A few vesicles containing horseradish peroxidase could be seen in the cytoplasm of the endothelium. Diffuse dispersion of tracer in the cytoplasm was not found. Reaction product was demonstrated in the subendothelial basement membranes of a few arteriolar segments, as under normal conditions.
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