Abstract
The peripheral and central anticholinergic potencies of six glycollic acid esters were measured and compared with similar results for atropine and hyoscine. There was no correlation between estimates of in vivo peripheral anticholinergic activity as measured by production of mydriasis in mice and by antagonism of oxotremorine-induced salivation in mice. The reason for this lack of correlation is not apparent. A significant correlation was demonstrated between estimates of central activity obtained by measuring antagonism of oxotremorine-induced tremors in mice and elevation of the EEG arousal threshold in cat encéphale isolé preparations. It is concluded that blockade of central cholinergic synapses was responsible for both effects and there is some discussion of the significance of the system involved in EEG arousal. The relationship between chemical structure of the drugs and their pharmacological activity is also discussed.
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