The Percentage of Peripheral Eosinophils as a Sensitive Marker for Differentiating FIGO Grade in Endometrial Adenocarcinomas

Abstract

Studies on eosinophils have mostly been directed to parasitic infections and allergic diseases, but the role of eosinophils in oncology has been largely ignored. Eosinophils are an important modulator of the immune response and components of the inflammatory process against the tumor. This study has been done to reveal the relationship between the data of 318 patients whose final pathology result was reported as a pure endometrioid type endometrial carcinoma (EC) and pre-operative peripheral blood eosinophil percentages.The data were analyzed in two groups as present/absent according to whether there are tumor metastases in the adnexes, lymph nodes, cervical stroma, and whether there is lymphovascular space invasion. FIGO grade was taken as basis in the evaluation of the tumor grade; Low-grade defines grade 1 or 2, and high-grade defines grade 3. The requirement for lymph node dissection was designed according to Mayo criteria. SPSS software program was used for statistical analysis.The mean percentage of eosinophils in high-grade patients was 2.75 ± 0.35, and it was statistically significantly higher than the mean percentage of eosinophils of 1.79 ± 0.09 found in low-grade patients (p= 0.013). In the ROC analysis, when the cut-off eosinophil percentage was taken as 1.95%, the sensitivity was calculated as 62% and specificity as 67% (p= 0.004).Eosinophil percentages which are a simple, easily accessible, and inexpensive method can be an important pre-operative predictive tool. Eosinophil percentages can be used in determining the need for surgical staging in EC.