The peptide β43–47 which increases microvascular permeability is released by plasmic during cleavage of fragment Y of fibrinogen

Abstract

A synthetic pentapeptide corresponding to sequence 43—47 of human fibrinogen Bβ chain elicited, in rabbits, antibodies that during immunoblotting recognized intact fibrinogen, fragments X and Y as well as the Bβ chain. Since fragment Y is the last peptide product which reacts with anti-β43–47 antibodies, splitting of fragment Y into fragment D and fragment E must be accompanied by plasmin cleavage of the peptide bond β-Lys-47-Ala-48.