Abstract
Introduction Acute Generalized Exanthematous Pustulosis (AGEP) is a dermatologic condition characterized by non-follicular sterile pustules on a background of edematous erythema. The most common offending drugs are antibiotics; however, we report a case of Pepcid (Famotidine) -induced AGEP. An 82-year old African American female with a known medical history of HTN, GERD, eczema, and glaucoma was brought to the ER after being found to be lethargic and difficult to arouse. Chief complaints included chills, fatigue, and dry skin with accompanying rash. The patient was hospitalized for treatment of pneumonia with Vancomycin and Rocephin. She was hospitalized two months prior for diffuse dermatitis with exfoliation and diagnosed with Eczema status post skin biopsy. Increasing her Famotidine dosage showed an exacerbation in her condition. Famotidine was discontinued, however her rash persisted and developed over time, leading to her present condition. The skin rash was found on the trunk, extremities, face, and scalp, soles, and mucosal membranes of the mouth. There was marked neutrophilia and light eosinophilia. The Anti-SSA and SSB came back negative ruling out Sjogren Syndrome as well as a negative skin biopsy ruling out bacterial infection. The patient is currently being treated with ammonium lactate lotion and prednisone. The pustules had disappeared by the 8th day of admission leaving dry skin and some scarring with continuing improvement. Discussion This case brings attention to an uncommon skin manifestation caused by a drug that does not have many documented cases of causing AGEP. Though rare, AGEP should be considered in patients that develop cutaneous manifestations with Famotidine treatment.
Published Version
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.