Abstract
Cortical folding is a highly regulated process involving amplification of neuroprogenitor cells, increased neurogenesis and migration of neurons along the tangential axis. A new paper in Development investigates the signalling processes behind cortical folding in mice, which have a smooth brain surface (lissencephaly) that evolved from the loss of folding present in gyrencephalic (folded cortex) mammals. To hear more about the story behind the paper, we caught up with the first author Matt Matrongolo and his supervisor Max Tischfield, Assistant Professor at Rutgers, The State University of New Jersey.
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