Abstract
Vascular development critically involves pruning, which helps to remodel an immature network containing excess microvessels into a mature and functioning one. The mechanisms of vascular remodelling and the relationship between the endothelial cells and the other cell types with which they are closely associated are, however, currently poorly understood. A new Development paper now demonstrates a crucial role for oxygen sensing by astrocytes in vascular remodelling of the mouse retina. We caught up with the two-author team behind the paper: research associate Li-Juan Duan and her supervisor Guo-Hua Fong, Professor of Cell Biology at the University of Connecticut Health Center, to hear more about the story.
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