Abstract
The present study was designed to elucidate the distribution patterns of 2-metoxy-4-(1-propenyl)-hydroxybenzene in the organism of the warm-blooded animals (rats) after its intragastric administration at a dose equivalent to three 50% lethal doses (LD-50) for this compound. 2-metoxy-4-(1-propenyl)-hydroxybenzene was extracted in the unmodified form from the organs and blood of the dead animals after the dualfold infusion of the tissues with ethyl-acetate and purification by chromatography on a macrocolumn with silica gel L 40/100 mcm making use of the hexane-acetone mixture (7:3) mobile phase as the eluent. TLC, HPLC, and UV-spectrometry were employed to identify and quantify the analyte. The study has demonstrated the presence of unmetabolized 2-metoxy-4-(1-propenyl)-hydroxybenzene in the organs and blood of the poisoned animals. The largest amounts of this compound (expressed in milligrams per 100 g of the tissue) were accumulated in the stomach with its contents (236.22±28.21), small intestine with their contents (122.29±15.55), lungs (44.28±2.10), and spleen (44.00±4.70).
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