Abstract
The Pathophysiology of Impulse control Disorders in Parkinson Disease
Highlights
Parkinson disease (PD) is a multisystem neurological condition estimated to affect 6–11 per 6,000 of the general UK population [1]
Five recent studies have confirmed that the use of medications in the management of PD can lead to the development of impulse control disorders (ICDs) in patients
Positive correlations found between the total daily levodopa equivalent dose (LED) of dopamine agonists (DAs) and impulsivity [26] provide a strong indication of the involvement of DAs in the development of ICDs in PD
Summary
Parkinson disease (PD) is a multisystem neurological condition estimated to affect 6–11 per 6,000 of the general UK population [1]. PD is characterised by the depletion of dopaminergic neurons in the substantia nigra, resulting in an imbalance of the basal ganglia circuitry. This depletion of dopaminergic neurons instigates a variety of symptoms, which can be broadly categorised into motor and non-motor. ICDs is an umbrella term covering a spectrum of conditions, which include pathological gambling and compulsive behaviours such as binge eating and hypersexuality [3] and is defined by the Diagnostic and Statistical Manual of Mental Disorders (DSM-IV-TR) as a failure to resist an impulse, drive or temptation to perform an act that is either physically, psychologically, socially, legally or financially harmful to the patient or others [4].
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