The pathophysiological role of inflammatory parameters in patients with varicocele.

Abstract

Varicocele is the abnormal enlargement of the pampiniform plexus in the scrotum and is one of the diseases that have negative consequences on reproduction in men today. The aim of this study is to investigate the pathophysiological role of inflammatory parameters in patients diagnosed with varicocele. Patients who applied to Viransehir state hospital urology outpatient clinic between January 2016 and January 2022 were evaluated retrospectively. Among the patients whose varicocele diagnosis was evaluated by physical examination, 112 patients diagnosed with Grade III varicocele were included in the study. Obtained hemogram results [red blood cell, red cell distribution width (RDW), mean red cell volume, white blood cell, hematocrit, hemoglobin, mean hemoglobin amount, platelet, platelet distribution width (PDW), neutrophil, lymphocyte, monocytes, and mean platelet volume (MPV)] were compared with the control group values. There was no statistical difference between the two groups in terms of mean age (p=0.270). Statistically significant parameters between both groups were erythrocyte (p=0.011), MCV (p=0.028), RDW (p=0.018), and PDW (p=0.004), respectively. However, Neutrophil/Lymphocyte ratio (NLR), PLT/Lymphocyte ratio (PLR) and MPV/PLT ratio (MPVPR) values were found to be statistically significantly higher in the varicocele group (p=0.034, p=0.043 and p=0.045, respectively). According to our results, it is possible to recommend using the inflammatory parameters as markers to screen for the pathophysiological basis of varicocele.