Abstract

Adenocarcinoma of the prostate (also referred to a prostatic carcinoma) comprises 95 % of prostatic neoplasms. The pathologic diagnosis of prostatic carcinoma is based on a combination of features. The diagnostic features are grouped into primary criteria (architectural) and secondary criteria (cytologic). Tertiary criteria (cytoplasmic and luminal) are supportive of the diagnosis. In diagnostically challenging cases, immunohistochemical stains are used to confirm the diagnosis. Mimickers of prostatic carcinoma are described, including clear cell cribriform hyperplasia, atrophy, basal cell hyperplasia, atypical adenomatous hyperplasia, and seminal vesicle epithelium.

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