Abstract
Infection of guinea pigs with guinea pig cytomegalovirus (GPCMV) results in an acute infection followed by chronic persistent infection. The severity of the acute phase of infection is dependent upon the strain of the host and whether the host is pregnant. During the persistent phase of infection, virus persists in the salivary glands, the pancreas, and lymphoid tissues. GPCMV infects the placenta of pregnant guinea pigs, crosses the placenta and infects the fetuses. Transplacental transmission of the virus can occur throughout the entire gestation period. The molecular cloning of approximately 97% of the GPCMV genome has made it possible to determine the DNA structure, generate restriction endonuclease maps of the DNA, identify regions of DNA sequence homology with human cytomegalovirus (HCMV), begin to analyze patterns of transcription, and detect GPCMV infection in cultured cells by in situ hybridization.
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