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Abstract
Abstract Corneal immune rings were produced with purified herpes simplex virus (HSV) antigen in both systemically and locally (intracorneal) HSV-sensitized rabbits. The ringlike corneal opacity consisted of a local accumulation of inflammatory cells, HSV antigen, host-antibody, and complement. A similar linear opacity was produced by injection of purified HSV antigen and anti-HSV antibody simultaneously at opposite sides of a normal rabbit cornea in a nonsensitized rabbit. Immunohistopathologic studies of experimental stromal herpes keratitis in rabbits induced by corneal infection with HSV revealed antigen, host-antibody, complement (C3), and inflammatory cells at the site of the stromal infiltrate. The tissue injury occurring in stromal herpes keratitis appears to result from HSV antigen-HSV antibody interaction; this attracts serum complement and results in the leukotaxis of polymorphonuclear leukocytes which constitute the major corneal infiltrate seen in stromal keratitis.
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