Abstract
Not long ago, the zona pellucida of the egg was broadly accepted as the main trigger of the acrosomal exocytosis. Recent evidence, however, demonstrated that most fertilizing mouse sperm undergo acrosomal exocytosis before binding to the zona pellucida of the eggs (Jin et al, 2011. PNAS; doi 10.1073/pnas.1018202108). These findings raised the question of where fertilizing spermatozoa initiate acrosome exocytosis (Buffone et al, 2014. Biol Reprod; doi 10.1095/biolreprod.114.117911). This article is protected by copyright. All rights reserved
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