Abstract
Chlorhexidine (CHX) is a synthetic cationic biguanide that harbors 2 biguanide groups both linked to a terminal 4-chlorophenyl group with the resultant chlorguanide structures connected by a hexamethylene bridge. Chlorhexidine can cause life-threatening anaphylaxis due to specific immunoglobulin E (sIgE) antibody–mediated activation of basophils and mast cells (MCs) and is generally associated with mucosal or parenteral exposure. Although it was originally thought to be very rare, in some countries, CHX has now become an important—often hidden and overlooked—cause of perioperative hypersensitivity (POH).
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: The Journal of Allergy and Clinical Immunology: In Practice
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
