Abstract
Sotiriades, in 1917, reported clinical improvement in the condition of a patient with acute malaria following the inoculation of 10 ml of serum obtained from a “chronic” case. Kauders confirmed this finding by observing that beneficial effects resulted in 9 of 12 patients who received small quantities of serum from a person difficult to infect with malaria. While these reports suggested that the passive transfer of malarial immunity was feasible the first convincing evidence was adduced by Coggeshall and Kumm. These authors showed that protection against Plasmodium knowlesi could be conferred upon non-immune rhesus monkeys through serum obtained from monkeys previously immunized against this parasite. Although the degree of protection achieved was variable, best results being obtained when parasitic inocula were small, this study clearly indicated the existence of protective antibodies in the blood of monkeys with established malarial infections.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: The American Journal of Tropical Medicine and Hygiene
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
