Abstract
ABSTRACT In non-insulinized alloxan diabetic pregnant rats an altered calciumphosphorus homeostasis was demonstrated and in addition morphological parathyroid changes occurred in the diabetic rats and their offspring. This was manifested by enlargement of the parathyroid glands and increased mitotic rate, suggesting parathyroid stimulation. The parathyroid volume in the offspring of the alloxan diabetic rats exhibited a significant negative relationship with the maternal serum calcium and a significant positive relationship with the maternal serum phosphorus. Hence it is reasonable to assume that the altered calcium-phosphorus homeostasis in the diabetic pregnant rats is responsible for the morphological changes in the foetal parathyroids.
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