Abstract
ABSTRACT The parathyroid morphology was studied in male rats following the administration of cortisone (1, 3 and 9 mg/day) and DOCA (0.5, 1.5 and 4.5 mg/day). The parathyroid volume and mitotic rate decreased after cortisone treatment, the findings being suggestive of an inhibition of parathyroid function. In the parathyroids of the DOCA-treated rats, there was an increased mitotic rate and an increased number of cells in DNA-synthesis as determined by an autoradiographic study after the administration of tritiated thymidine, indicating an increased activity of the glands. The serum potassium and the renal concentrating capacity, measured as urine osmolality, were significantly lowered and the urinary volume significantly increased in the DOCA-treated rats but these showed no significant changes in total serum calcium and phosphorus. An explanation of the increased parathyroid activity in the DOCA-treated rats might be that DOCA causes hypokalaemic nephropathy and alkalosis with lowering of the plasma ionized calcium level.
Published Version
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