Abstract
Sulphur-containing analogues of d-glucose were tested for effects on insulin release, d-glucose transport and d-glucose oxidation in microdissected pancreatic islets of obese-hyperglycemic mice. Substituting sulphur for oxygen in the ring structure of d-glucose (5-thio- d-glucose) resulted in a total loss of insulin-releasing ability. 5-Thio- d-glucose inhibited d-glucose-stimulated insulin release, d-glucose oxidation, and to a lesser extent d-glucose transport. Another d-glucose analogue, containing sulphur bound to carbon 1 (1-thio-β- d-glucose) did not influence d-glucose transport or oxidation. Whether 1-thio-β- d-glucose affected insulin release could not be decided because this compound appeared to destroy the insulin molecule. The results are compatible with the hypothesis that D-glucose metabolism plays a role in the recognition of this sugar as an insulin secretagogue.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
