The palladium-catalyzed Heck arylation of olefins with arenediazonium salts as a sustainable strategy in organic synthesis

Abstract

The palladium-catalyzed Heck arylation of olefins using arenediazonium salts, known as the Heck–Matsuda reaction, constitutes an effective, green, and sustainable way to synthesize functionalized aryl intermediates for organic synthesis. The present review highlights this strategy focusing on some selected examples from our laboratory. The examples include the substrate-directed arylation of olefins — covalent and noncovalent strategies — and their application in the total syntheses of many pharmacologically active compounds, commercial drugs, and/or functional compounds.