Abstract
Light microscopy (Nissl staining, computerized morphometric analysis), electron microscopy (using criteria for assessment of the functional state of neurons), and the TUNEL method for identifying apoptotic cells were used to undertake a comparative analysis of the structural-functional organization of the paleoamygdala. The results of this analysis suggested that limbic brain structures are involved in the pathogenesis of absence epilepsy. The area occupied by the amygdaloid body on sections was significantly greater in WAG/Rij rats (a model of absence epilepsy). Assessment of the ultrastructural characteristics of neurons in all paleoamygdala structures (the dorsomedial, posterior medial, and posterior cortical nuclei) in WAG/Rij rats identified decreases in their functional activity. In addition, WAG/Rij rats showed an increased number of pyknomorphic neurons with signs of apoptosis identified by the TUNEL method, pointing to destructive processes.
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