Abstract
The objective of the study was to evaluate the efficacy and ease of treatment of an oral meloxicam suspension for the treatment of chronic musculoskeletal lameness in horses. A crossover palatability study consisting of 30 healthy horses and ponies was conducted to compare the time to consume a 400-gram meal of oats alone to a 400-gram meal of oats top dressed with meloxicam oral suspension (MOS) (0.6 mg/kg body weight [BW]). The mean time to consume a 400-gram meal of oats only was 301.0 ± 145 seconds and was 286.3 ± 125.6 seconds for MOS. There was no difference between the consumption duration times of oats with or without MOS. Horses (77) were enrolled into a blinded, active-controlled, randomized clinical study. Treatment 1 consisted of animals receiving MOS (0.6 mg/kg BW q24 hours for 5 days), and treatment 2 consisted of animals receiving phenylbutazone paste (1 g/454 kg BW, q12 hours for 5 days). Animals were treated on day 0 and evaluated for lameness associated with of musculoskeletal disease on day 5. For both treatments 1 and 2, the day 5 lameness scores were significantly less than the day 0 lameness scores. At a walk and trot, there were no differences in efficacy between phenylbutazone and MOS (based on absolute score values, differences in scores between day 0 and day 5, and proportion of horses responding to treatment). It was concluded that MOS was palatable and effective for the treatment of musculoskeletal disease.
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