Abstract
Some patients complained of local pain in injection site or withdrew limbs during rocuronium bromide injection. The possible mechanism may be concerned with low pH of the muscle relaxant, a kininogen cascade and the responses of mast cell and C nerves fiber ending to rocuronium stimulation. Pretreatment with intravenous lidocaine, fentanyl - like drugs, ondansetron, dexmedetomidine, tramadol, ketamine of subthreshold dose or 8.4% sodium bicarbonate evidently decreases the incidence rate and degree of rocuronium-induced pain. Key words: rocuronium; injection; pain
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