Abstract
The p53 family of tumor suppressors, which includes p53, p63, and p73, has a critical role in many biological processes, such as cell cycle arrest, apoptosis, and differentiation. In addition to tumor suppression, the p53 family proteins also participate in development, multiciliogenesis, and fertility, indicating these proteins have diverse roles. In this review, we strive to cover the relevant studies that demonstrate the roles of p53, p63, and p73 in lipid and iron metabolism.
Highlights
INTRODUCTIONReviewed by: Koji Itahana, Duke-NUS Medical School, Singapore Qing Feng, Nanjing Medical University, China
Edited by: Kanaga Sabapathy, National Cancer Centre Singapore, SingaporeReviewed by: Koji Itahana, Duke-NUS Medical School, Singapore Qing Feng, Nanjing Medical University, ChinaSpecialty section: This article was submitted to Molecular and Cellular Pathology, a section of the journal Frontiers in Cell and Developmental BiologyReceived: 27 May 2021 Accepted: 08 July 2021 Published: 29 July 2021Citation: Laubach K, Zhang J and Chen X (2021) The p53 Family: A Role in Lipid and Iron Metabolism
We focus on the role of the p53 family proteins in cholesterol and fatty acid metabolism
Summary
Reviewed by: Koji Itahana, Duke-NUS Medical School, Singapore Qing Feng, Nanjing Medical University, China. In TP53, promoter 1 (P1) gives rise to two translation initiation start sites, termed ATG1 and ATG40, which produce full-length p53 (FLp53) and 40p53, respectively (Courtois et al, 2002; Yin et al, 2002) Both isoforms possess transactivation function even though 40p53 contains a truncated form of the conventional transactivation domain (Zhu et al, 1998; 2000; Harms and Chen, 2005). By using promoter 2 (P2), all family members produce the N-terminally truncated isoforms, termed 133p53 and 160p53 in TP53, which arise from translation initiation start sites ATG133 and ATG160 (Bourdon et al, 2005), and Np63/73 in TP63/73 (Yang et al, 1998; 2000).
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
