Abstract
Whether P2 purinoceptors modify ischaemic tolerance in mammalian myocardium is not known. We investigated effects of the P2Y receptor agonist UTP on functional tolerance to ischaemia, in Langendorff-perfused C57/Bl6 mouse hearts subjected to 20 min ischaemia/45 min reperfusion. Hearts were untreated or subjected to: i) 5 min pre-ischaemic UTP; ii) 5 min post-ischaemic UTP; or iii) 5 min pre-and 5 min post-ischaemic UTP treatment. Low (250 nM) and high (1 μM) UTP was assessed. Untreated hearts recovered 67±3 mmHg left ventricular developed pressure (LVDP; ∼50% of pre-ischaemia), and exhibited sustained diastolic contracture (31±2 mmHg) after 45 min reperfusion.
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