Abstract
Abstract The authors report oxygen enhancement ratio measurements for protracted irradiation of human cancer cells in culture, using 252Cf neutron sources and 137Cs gamma-ray sources. A value of 1.55 was found for 252Cf, which is in general agreement with other reported OERs; the value of 2.50 for 137Cs is significantly higher than some previously reported. The therapeutic gain factor of 1.6 indicates that 252Cf may yield an advantage in implant therapy. Glass flasks were used to obviate the problem of oxygen solubility in plastic flasks. Improvements in gassing procedures produced reasonably good survival in control cells under prolonged anoxia.
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