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Abstract
Hydroxyurea was used to produce a synchronously dividing population of Chinese hamster cells. The x-ray sensitivity was measured under aerated and hypoxic conditions as a function of stage in the generation cycle. The pattern of response to a single dose of 800 rads in air or 2000 rads under hypoxia was very similar, implying no significant change in the oxygen enhancement ratio with stage in the generation cycle. Full dose-survival curves under aerated and hypoxic conditions were obtained for cells in mitosis and for cells in the DNA synthetic period. These stages in the cycle represent the extremes of radiosensitivity; the survival curves differed principally in extrapolation number rather than slope. Cells in both of these stages of the generation cycle exhibited an oxygen enhancement ratio close to 2.6.
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