Abstract
Objective:A permanent balance exists between the production and elimination of reactive oxygen species in all living organisms. The aim of this study was to evaluate the effects of sevoflurane possibly causing an imbalance in the equation of reactive oxygen species on the female rat reproductive system.Materials and Methods:A total of 30 adult female Wistar-albino rats were placed into an anesthesia chamber to administer sevoflurane. Rats were randomly divided into six groups, each group consisting of five rats: the control group received 2 L/min O2 18 min/day for seven days; the first group received 1 minimum alveolar concentration (MAC) of sevoflurane and 2 L/min O2 18 min/day for seven days; the second group received 1 MAC of sevoflurane and 2 L/min O2 18 min/day for seven days with no treatment for the next seven days; the third group received 1 MAC of sevoflurane and 2 L/min O2 18 min/day for 14 days; the fourth group received 1 MAC of sevoflurane and 2 L/min O2 18 min/day for 14 days with no treatment for the next seven days; and the fifth group received 1 MAC of sevoflurane and 2 L/min O2 18 min/day for 14 days with no treatment for the next 14 days. Bilateral ovaries were subsequently removed for biochemical analysis of tissue anti-oxidative enzyme levels.Results:Slight fluctuations were detected in mean nitric oxide, prostaglandin E2, prostaglandin F2-alpha, superoxide dismutase, glutathione peroxidase, malondialdehyde, alginate dialdehyde, and xanthine oxidase levels between the groups; however, the differences were not significant (p>0.05).Conclusion:Sevoflurane has no effect on the activity of anti-oxidant systems in the rat ovary.
Highlights
Sevoflurane [2,2,2-trifluoro-1- ethyl fluoromethyl ether], which has a boiling point of 58.6 °C, a vapor pressure of 160 mm hemoglobin at 20 °C, and a blood-gas partition coefficient of 0.69, is pleasant-smelling and relatively non-irritating to the airways providing a high inhaled concentration without any adverse effects or irritation[1]
Slight fluctuations were detected in mean nitric oxide, prostaglandin E2, prostaglandin F2-alpha, superoxide dismutase, glutathione peroxidase, malondialdehyde, alginate dialdehyde, and xanthine oxidase levels between the groups; the differences were not significant (p>0.05)
Superoxide dismutase activity has been shown in the granulose and theca cells of the follicle, where glutathione peroxidase enzyme is localized in follicular fluid[2]
Summary
Sevoflurane [2,2,2-trifluoro-1- (trifluoromethyl) ethyl fluoromethyl ether], which has a boiling point of 58.6 °C, a vapor pressure of 160 mm hemoglobin at 20 °C, and a blood-gas partition coefficient of 0.69 (approximately half of isoflurane), is pleasant-smelling and relatively non-irritating to the airways providing a high inhaled concentration without any adverse effects or irritation[1]. A study conducted by Yalçınkaya et al[4] on the effects of follicular fluid nitric oxide, malondialdehyde, and reduced glutathione on in vitro fertilization outcomes demonstrated that malondialdehyde level was high in the follicular fluid of women with pregnancy, whereas nitric oxide was low. They found that a positive correlation existed between malondialdehyde levels and the number of grade 1 embryos, and fertilization rates[4]. The present study aimed to evaluate the impact of sevoflurane on the oxidant/anti-oxidant systems in the female reproductive tissue of rats
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