Abstract
Tryptamine solutions were incubated with crude suspensions of rat and guinea pig tissues in the Barcroft-Warburg apparatus. Oxygen consumption was measured. Solutions incubated for various periods of time were deproteinized with perchloric acid, and the supernatant fraction was examined in the Beckman DU spectrophotometer. Consistent and marked changes were found in the ultraviolet absorption spectrum of the tryptamine solutions. The quantitative changes have been utilized for the measurement of monoamine oxidase activity by the "substrate disappearance" method. The significance of the qualitative changes in absorption spectrum is discussed. Similar experiments with 5-hydroxytryptamine are presented. This substrate is oxidized by rat liver at about the same rate as tryptamine.
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