Abstract
Vanadyl (V (IV)) salts autoxidize in neutral aqueous solution yielding O 2 − plus vanadate (V (V)) and these, in turn, cause the oxidation of NADH, by a free radical chain reaction. This oxidation of NADH was inhibited by superoxide dismutase, but not by a scavenger of HO.. When H 2O 2 was present V (IV)) caused rapid oxidation of NADH by a process which was unaffected by superoxide dismutase but was inhibited by a scavenger of HO.. This appeared to be dependent upon reduction of H 2O 2 to OH − plus HO., by V (IV)), followed by oxidation of NADH by HO.. Since there are reductants, within cells, capable of reducing V (V)) to V (IV), these reactions are likely to contribute to the toxicity of vanadate.
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