Abstract
Oceans have shown to be a remarkable source of natural products. The biological properties of many of these compounds have helped to produce great advances in medicinal chemistry. Within them, marine natural products containing an oxepanyl ring are present in a great variety of algae, sponges, fungus and corals and show very important biological activities, many of them possessing remarkable cytotoxic properties against a wide range of cancer cell lines. Their rich chemical structures have attracted the attention of many researchers who have reported interesting synthetic approaches to these targets. This review covers the most prominent examples of these types of compounds, focusing the discussion on the isolation, structure determination, medicinal properties and total synthesis of these products.
Highlights
More than 70% of Earth surface is covered by water, 96.5% of which is found in the oceans.This means that the planet’s largest habitat is the ocean, which is the ecosystem where the major part of animals and plants of Earth lives
Aplysistatin was first isolated from the South Pacific Ocean sea hare Aplysia angasi in 1977 [8]
Their an alternative route based on the formation the12-hydroxypalisadin oxepanyl derivative systems, andstrategy appliedfollowed it to the synthesis of aplysistatin, palisadins
Summary
More than 70% of Earth surface is covered by water, 96.5% of which is found in the oceans. Natural products containing an oxepanyl moiety have been frequently found in sponges, corals, or different marine fungus, within others Their interesting biological properties include anticancer, antibacterial or antifungal activities. We B could mention manysubstances other families and examples of marine natural products that bear the oxepane moiety (spiroxins, phomactins, clavulazols, etc.) but review. Some isolated examples of the compounds described hereother are present in otherexamples reviews devoted to marine described triterpeneshere [6] or marine natural work. Some isolated of the compounds are present in described here are present in other reviews devoted to marine triterpenes [6] or marine natural products [7].
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