Abstract
Some related reports indicate that the outer retinal membrane protein 1 (ROM1) functions importantly in the regulation of the biological process of tumor. Nevertheless, studies towards the role of ROM1 in lung cancer are few. Here, our data demonstrated that ROM1 displayed a relation with lung cancer tumorigenesis and development. In the Tumor Genome Atlas (TCGA) cohort, reduced ROM1 level was observed in lung cancer tissues, instead of normal tissues. After bioinformatics analysis, the data revealed that ROM1 level was associated with the tumor stage. Additional results indicated that highly expressed ROM1 exhibited a positive correlation with the overall survival rate, and ROM1 was probably a promising prognostic biomarker of lung cancer. Additionally, our results indicated that knocking out ROM1 could promote cell proliferation, migration, and invasion. Our data conclusively demonstrated that ROM1 modulated lung cancer tumorigenesis and development, as a prognosis and treatment biomarker.
Highlights
In China, lung cancer is a widely occurring cancer and the primary cause of cancer-associated mortality
Statistics illustrated that the ratio of non-small-cell lung cancer (NSCLC) patients took up 80% to 85% over total types of lung carcinoma [2, 3], and 30% of NSCLC patients entered stage III at the time of diagnosis and missed the best opportunity for surgical treatment
Our data revealed that compared to 347 normal tissues, ROM1 expression was greatly reduced in 483 lung adenocarcinoma (LUAD) tissues
Summary
In China, lung cancer is a widely occurring cancer and the primary cause of cancer-associated mortality. Statistics illustrated that the ratio of non-small-cell lung cancer (NSCLC) patients took up 80% to 85% over total types of lung carcinoma [2, 3], and 30% of NSCLC patients entered stage III at the time of diagnosis and missed the best opportunity for surgical treatment. Surgical intervention is the most suitable for early lung cancer diagnosis and thought to be the best treatment option [5]. Much progress in treatment and diagnosis, such as immunotherapy and tumor genomics, has made a huge improvement in the survival of lung cancer [8, 9]. Lung cancer has become a successful example of molecular targeted therapy in solid tumors [10]
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