Abstract
IntroductionDapagliflozin is a member of a novel class of drugs (sodium-glucose cotransporter-2 inhibitors) used to treat type 2 diabetes mellitus and licensed in Pakistan in 2017. This retrospective observational study evaluated the effects of dapagliflozin on glycated hemoglobin (HbA1c) concentrations in patients treated at endocrinology clinics in Islamabad, Pakistan. The secondary objectives included assessing the effects of dapagliflozin on weight reduction and blood pressure control and to determining its safety.MethodologyPatients with type 2 diabetes who were treated with dapagliflozin were identified by screening the electronic medical records at tertiary care hospitals in Islamabad. Data were collected at the first visit and at follow-up. Categorical variables were recorded as frequencies and percentages and compared by McNemar’s tests, and continuous variables were recorded as means and standard deviations and compared by paired sample t-tests.ResultsMean HbA1C concentration was significantly lower at follow-up than at the first visit (7.57%±0.98% vs. 9.07%±2.07%, respectively; p<0.001). Bodyweight (85.09±15.92 kg vs. 87.07±16.11 kg, respectively; p<0.001) and diastolic blood pressure (80.34±7.12 mmHg vs. 82.34±9.61 mmHg, respectively; p<0.001) were also significantly lower at follow-up than at the first visit, whereas systolic pressure showed a marginally significant reduction (123.5±16.57 mmHg vs. 126.83±19.97 mmHg, p=0.048).ConclusionThis first observational study of patients in Pakistan treated with dapagliflozin found that HbA1c concentration, weight, and blood pressure were reduced after initiation of dapagliflozin treatment.
Highlights
Dapagliflozin is a member of a novel class of drugs used to treat type 2 diabetes mellitus and licensed in Pakistan in 2017
This retrospective observational study evaluated the effects of dapagliflozin on glycated hemoglobin (HbA1c) concentrations in patients treated at endocrinology clinics in Islamabad, Pakistan
The proportion of patients with HbA1c >9% decreased significantly, from 41.26% (n=170) at baseline to only 5.58% (n=23) at follow-up. These findings indicated that dapagliflozin-associated improvement was greater among patients with poor glycemic control, despite the study cohort being younger and having a longer duration of diabetes than other study cohorts
Summary
This retrospective observational study involved patients evaluated at endocrinology clinics of Shifa. How to cite this article Kamin M, Ishtiaq O, Raashid K, et al (June 11, 2020) The Outcomes of Dapagliflozin Use in Real-Life Clinical Settings in Endocrinology Clinics of Islamabad, Pakistan. International Hospital and Umar Diabetes and Foot Care Centre in Islamabad, Pakistan. All patients with type 2 diabetes, who were treated with dapagliflozin, were identified by screening electronic medical records at these hospitals. Patients were included if they had been diagnosed with type 2 diabetes for at least six months and were treated with dapagliflozin as monotherapy or combined with one or two other oral agents or insulin. Patients were excluded if they had type 1 diabetes, a glomerular filtration rate (GFR)
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