Abstract
The Outcome of Tumor Ablation Therapies is Determined by Stress Signaling Networks
Highlights
Prominent roles in interventional oncology are held by various tumor ablation therapies performed by direct applications of local acute trauma-inducing insult to the targeted lesion aiming for its rapid in situ destruction
These types of stress provoke evolutionary well conserved canonic protection mechanisms based on cellular stress signaling network that serves to re-balance biochemical activities within the cell
Stress signaling network consist of interlinked intracellular signal transduction programs providing defense mechanisms for mitigating stress challenge expressed as adaptive responses developed to assure restored homeostasis and survival of afflicted cells
Summary
Prominent roles in interventional oncology are held by various tumor ablation therapies performed by direct applications of local acute trauma-inducing insult to the targeted lesion aiming for its rapid in situ destruction. Common injury inflicted in cells of tumors treated by ablation therapies is the impairment of proteostasis due to accumulation of misfolded/damaged proteins. The aim of this commentary is to emphasize that the activity of the engaged intracellular signaling pathways determines the fate of involved tumor cells and the outcome of the applied therapies.
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